Radiosynthesis 14c

Iodine Along with the growth of contract research organizations for preparative organic synthesis and process development over the past decades, a subset of these enterprises have developed capabilities for the preparation of isotopically labeled compounds. Before that time, even relatively simple isotopically labeled materials were only accessible on an ad hoc basis, and depended on the capability and determination of individual researchers. These days, all but the most esoteric substances can be obtained from CROs, and this avenue can be explored before committing to an in-house program, especially for radiolabeled compounds. Hydrogen isotopes 2H, 3H Tritium labeling is one of the subjects of a recent monograph.

Radiosynthesis 14c

Formula CAS Radiolabeled Test Articles A radiolabeled Radiosynthesis 14c article can be used to establish the pharmacodynamic and pharmacokinetic profile of a given molecule.

These types of studies called DMPK are done in vivo using different animal models. Often, the bottleneck in launching DMPK programs is the availability of the radiolabeled drug.

Due to the Radiosynthesis 14c and expertise involved in manipulating radioactive materials, radiosynthesis is a resource that is not always available to companies involved in drug development and an outsourcing partner, like AptoChem, must be found to prepare a radiolabeled drug.

A compound with 14C labelling will have only a radioactive beta decay, which is a non-ionizing type of radiation and is much safer to handle then a gamma emitting isotope. The length of a given radiosynthesis will vary greatly depending on the complexity of the target molecule and the radioactive reagents available for 14C labelling and those are very limited For instance, in some rare occasion, the radiosynthesis pathway used can be exactly the same as for the unlabeled drug.

But in most cases, the preferred strategy will be to synthesize a known radiolabeled drug intermediate and complete the 14C labelling using a known pathway. It is also possible that AptoChem will have to design a completely new radiosynthesis strategy to produce the radiolabeled drug.

The amount of radioactivity and specific activity of a given radiolabeled drug will be two essential parameters to be determinate in order to meet the DMPK study requirement.

C-14 labeling

The amount of radioactivity will depend on the number of models to be dosed and at which dose. The specific activity is dependent on the radioisotope used. In theory, the maximum available specific activity for 14C labelling would be In practice, there is no complete enrichment in 14C and the maximum SA achievable should be between 40 to 60 mCi per mmol.

So, for a radiosynthesis that would include only one 14C label, it is possible to have a specific activity a little above 50 mCi per mmol.


In a DMPK study where the radiolabeled drug will have a high molecular weight and would require a small dose of test article, it is possible to incorporated more than one 14C label to obtain a specific activity suitable for the study requirements.

For example, with two 14C labels, it would be possible to have a specific activity a little above mCi per mmol.Selcia’s expertise in radiochemistry allows us to prepare custom 14C radiolabeled compounds of almost any complexity for use in pre-clinical and clinical studies. Rapid radiosynthesis of [11 C] and [14 C]azelaic, suberic, and sebacic acids for in vivo mechanistic studies of systemic acquired resistance in plants.

A new disaccharidase inhibitor, AO, showed fold more potent inhibition of purified rat small intestine sucrase-isomaltase (S-1) complex and fold more potent inhibition of. A high yield radiosynthesis of dl-amphetamine C was developed using c.

of benzoic C acid as the starting material. The dl-amphetamine-7 14 C was resolved in 84 per cent yields by the successive crystallization of d-amphetamine C d-bitartrate and l-amphetamine C l-bitartrate salts.

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@article{osti_, title = {Rapid radiosynthesis of [11C] and [14C]azelaic, suberic, and sebacic acids for in vivo mechanistic studies of systemic acquired resistance in plants}, author = {Best M. and Fowler J. and Best, M. and Gifford, A.N. and Kim, S.W. and Babst, B. and Piel, M. and Roesch, F.

and Fowler, J.S.}, abstractNote = {A recent. Selcia Radiolabelling.

Radiosynthesis 14c

Radiochemistry is our core competence making Selcia the company of choice for the custom synthesis of carbon radiolabelled compounds to support your regulatory, 14C Custom Radiosynthesis / 14C GMP API for Clinical Trials / GLP Analytics-GLP NMR / Metabolite & Impurity Synthesis.

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14C Radiosynthesis - Custom C14 Radiolabelling Techniques | Pharmaron